ABSTRACT
Long before the discovery of microbes, plants were well known for their healing potential against different diseases including infectious diseases. MDR (Multi Drug Resistant) bacteria are a source of major concern for clinicians as most primary antibiotics do not work against them. Due to this, there is a drastic increase in the number of infections caused by MDR strains which in turn leads to an increasing number of deaths due to lack of treatment. The aim of this study is to determine the anti-microbial properties of the extract of Phyllodium longipes, a lesser-known edible plant valued for its medicinal properties. However, its antimicrobial properties are largely unknown. In this study we explored its antimicrobial property against some pathogenic bacteria including MDR strains. The Minimum Inhibitory Concentration (MIC) of the ethanol extract of the plant was determined. This study shows that the plant extract is highly effective against Gram positive bacteria MRSA (Methicillin Resistant Staphylococcus aureus), Gram negative bacteria Klebsiella pneumoniae and Salmonella typhi, while it is mild to moderately effective against other pathogenic bacteria.

ABSTRACT
Background: The World Health Organization (WHO) classifies substance abuse as one of the frequent activities that constitute "negative risk-taking," particularly among teenagers and young adults. Objective: We assessed the prevalence, correlates and effects of substance abuse among pharmacy students in a Nigerian university. Methods: This study was a questionnaire-based prospective cross-sectional study. Descriptive statistics of frequency, mean, and standard deviation was used to summarize the data, The relationship between categorical variables was determined using the Pearson Chi square (X2) test, with a P value of <0.05 considered statistically significant. Results: Overall, 150 questionnaires were distributed for the study and retrieved. 147 (98%) of the participants were aged 20-25 years, 2 (1.3%) of the participants were aged 25-30 while 1 (0.7%) was above 35years. Out of the 150 participants, 75 (50%) were males and 75 (50%) were females. Most of the participants 98 (65.3%) were in 400 level while the rest52 (34.7%). About 136 (90.7%) of participants disagreed to having family history of alcohol use while 14 (9.3%) agreed to that. Most of the participants 124 (82.7%) were actively involved in religion. The p-value for the use a substance before passively was p= 0.000 and actively p= 0.000. Conclusion: The prevalence of substance abuse among the respondents was high. The lifestyle of people in their immediate environment significantly affects the therapeutic outcome of patients directly or indirectly. Alcohol was the most abused substance. Stress relief, peer pressure, curiosity and recreation have been identified as the major reasons why the students abuse drugs. It is expected that health providers maintain high level of health standard both physically and psychologically in order to be fit enough to administer treatment to the public. For this reason, proper attention must be given to health providers in their formative years in college to reduce to the ba

ABSTRACT
This study investigated the neurologic effect of Telfairia occidentalis on cadmium chloride-induced toxicity in male rats. Twenty-five male rats were grouped as follows: Group A: control, Group B-E: CdCl₂ 0.5ml; CdCl₂+ T. occidentalis 0.3ml; CdCl₂+T. occidentalis 0.5ml and CdCl₂+ T. occidentalis 0.7ml, respectively. Gas chromatography coupled to flame ionization detector, Ultraviolet visible ray spectrophotometry and total antioxidant capacity of T. occidentalis was done. Oxidative stress markers, muscle function markers and plasma electrolyte were assayed. The gait parameters of the animals were observed using gait test apparatus. This study lasted for 4 weeks. Blood and brain samples were collected. The phytochemical results revealed alkaloids, flavonones, terpenes, phenols, anthrocyanins and epicatechin. The biochemical results were in comparison with control and group B. The results were statistically significant at 95% confidence interval. MDA decreased in groups C, D and E, PC decreased in groups C, D and E and F2ISOP decreased in group C, D and E. An increase in SOD, CAT, GPx and GSH in groups C, D and E. A decrease in plasma creatine kinase level and an increase in AChE levels of groups C, D and E was revealed. There was no change in level. SL, SDL and BOS values increased in groups C, D and E. This study revealed that T. occidentalis has the tendency to ameliorate neurotoxicity and anemia induced by cadmium chloride.

ABSTRACT
The preformulation investigation commences upon the introduction of a new molecule. It encompasses the examination of physical, chemical, analytical, and medicinal aspects associated with molecules and offers insights into appropriate modifications to enhance molecular performance. The study of preformulation parameters is associated with the development of effective, safe, stable, and dependable pharmaceutical formulations. Famciclovir is a diacetyl-6-deoxy derivative of penciclovir. All of this is absorbed upon oral administration and is rapidly converted to penciclovir through deacetylation in the digestive tract, blood, and liver; subsequently, it is oxidized by the liver at position 6 of the purine cycle. The half-life of the dynamic intracellular medication, penciclovir triphosphate, is significantly prolonged, allowing for a once-daily dosage. Famciclovir is effective against genital herpes and the varicella-zoster virus. The primary aim of the preformulation studies of Famciclovir is to produce knowledge that aids in the development of stable and bioavailable dosage forms.

ABSTRACT
The significant phytochemical, anti-inflammatory, anthelmintic, antacid, anti-proliferative, therapeutic applications, antibacterial, and analgesic properties of Desmodium triflorum (L.) DC., family Fabaceae, were reviewed. The review describes the pharmacological and biological properties of Desmodium triflorum extracts in addition to their traditional usage. The strong antioxidant activity and the inhibition of α-amylase and α-glucosidase may be linked to various associated activities. Ursolic acid, Vitexin, Genistin, Fucosterol, and 2-Glucosylvitexin, are among the chemical elements of Desmodium triflorum that may contribute to the effects that have been documented. There is a need for more well planned, controlled clinical trials using formulations with phytochemical characterization. Additionally, the interest in different pharmaceuticals and cosmeceuticals sectors may be characterised by the unique bioactive substance's multiple biological potencies.

ABSTRACT
The use of plant-based natural products as medicine is a common practice in low income countries. In cultures Justicia carnea (JC) is mainly cultivated because of its perceived hematinic effect. The study involved a total of twenty-five wistar rats separated into five groups of five rats each. Group 1 served as control and received distilled water. Groups 2 to 5 received respectively a single oral dose of 30mg/kg indomethacin (Sabiu et al., 2015). While group 2 remained untreated (Indomethacin-only group), groups 3, 4 and 5 respectively received in addition 200mg/kg, 500mg/kg and 1000mg/kg of JC leaf extract for 14 days. The results showed that at lower concentrations (200mg/kg and 500mg/kg) there were no significant changes in the measured hematological parameters. The 1000mg/kg JC caused significant rise in red blood cell count, packed cell volume and lymphocytes but depressed neutrophils without any significant effects on the platelet count. Conclusively, consumption of high concentrations of Justicia carnea leaves improves red blood cell count and thus possibly ameliorates indomethacin induced anemia in wistar rats. Although, JC leaves did not cause any significant changes in the platelet count, it significantly reduced neutrophils and elevated lymphocytes.

ABSTRACT
Background: An inflammatory, prevalent, and chronic skin disease is psoriasis. The term "classic skin lesions" refers to the erythematous, scaly, and well-defined plaques that are frequently located on the extensor surfaces. There have also been several psoriasis variations reported, such as the guttate, erythrodermic, pustular, and palmoplantar types. Psoriasis is typically diagnosed clinically, although distinctive histologic findings include a lymphocytic infiltration, dilated blood vessels, and hyper- and parakeratosis of the epidermis. Although the exact cause of psoriasis is unknown, genetic and environmental factors have been linked to the immune-mediated disease. Many health advantages are associated with flavonoids, such as their antiviral, anticancer, and antioxidant qualities. They also have cardio- and neuroprotective properties. The kind of flavonoid, its (potential) method of action, and its bioavailability all affect these biological functions. These reasonably priced pharmaceutical ingredients contain substantial biological activities and have been shown to be beneficial for a range of illnesses. Purpose: The present study was conducted to evaluate the efficacy of new flavonoid derivatives for their anti-psoriatic potential. Methodology: The scientific validation of the present work was conducted using a computational molecular docking analysis of the lead compounds luteolin, baicalein, and myricetin against the PDE4 enzyme. Result: The results of the current analysis indicate that the selected lead compounds are efficient anti-psoriatic agents, demonstrating binding affinities to the target protein PDE4 with binding energies of -7.269, -7.16, and -6.64 kcal/mol for baicalein, luteolin, and myricetin, respectively. Conclusion: The results demonstrated that each chosen lead compound for further study exhibited substantial inhibitory efficacy against PDE4, hence indicating its potential as an anti-psoriatic drug.