EAS Publisher | Preformulation Studies of Famciclovir: Vital Part of Formulation Design

Preformulation Studies of Famciclovir: Vital Part of Formulation Design

DOI : https://doi.org/10.36349/easjpp.2025.v07i02.001

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The preformulation investigation commences upon the introduction of a new molecule. It encompasses the examination of physical, chemical, analytical, and medicinal aspects associated with molecules and offers insights into appropriate modifications to enhance molecular performance. The study of preformulation parameters is associated with the development of effective, safe, stable, and dependable pharmaceutical formulations. Famciclovir is a diacetyl-6-deoxy derivative of penciclovir. All of this is absorbed upon oral administration and is rapidly converted to penciclovir through deacetylation in the digestive tract, blood, and liver; subsequently, it is oxidized by the liver at position 6 of the purine cycle. The half-life of the dynamic intracellular medication, penciclovir triphosphate, is significantly prolonged, allowing for a once-daily dosage. Famciclovir is effective against genital herpes and the varicella-zoster virus. The primary aim of the preformulation studies of Famciclovir is to produce knowledge that aids in the development of stable and bioavailable dosage forms.

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