ABSTRACT
Abstract: Fournier’s gangrene is a necrotising fasciitis of the perineum due to synergistic infection. The aim of this study is to know the presentation and the predisposing factors of Fournier’s gangrene and the various management modalities. This is a retrospective study over the period of 2 years from June 2018 to June 2020. In which there were a total of 35 patients included and were analysed for the age at presentation, duration of symptoms at presentation, associated co-morbidities, isolated organisms and the length of stay in the hospital. Most of the patient’s age was above 50 years and had associated co-morbidities like diabetes mellitus. At presentation the patients were in SIRS and were subjected to immediate surgery followed by broad spectrum antibiotics and regular dressing. Once the wound was healthy either primary closure was done or skin grafting was done. Despite of advances in medical field the mortality remained pretty high in Fournier’s gangrene cases.

ABSTRACT
Abstract: Traumatic head injuries are a prominent cause of death. The privilege of intracranial hemorrhage is one of the fatal problems. CT-scan is considered the gold standard for the traumatic brain injuries diagnosis. GCS of the patients is helpful in patient evaluation. Patient with high GCS are neglected but it may be considered that they can develop significant problems. However, it is controversial whether to perform CT-scan in patients that have 13-15 GCS or not. Purpose: I hereby to evaluate the patients of head trauma with high GCS 10-15 on CT-scan that may be neglected but they may develop symptoms. My aim of study was to determine whether it is safe to discharge such patients or performing CT scan is safe. Besides this, I mainly found the frequency of different types of ICH in 50 patients that have 10-15 GCS. Approach: 50 patients of head trauma injuries were evaluated on computed tomography. All the patients had undergone non-contrast computed tomography scan of brain with the axial images and slice thickness of 5mm from foramen magnum to vertex. A Performa was filled for patient’s name, age, gender and other findings. Any statistical variables were correct by putting some exclusion criteria i.e. bleeding disorder and anti-coagulant therapy so that it might not influence the desired conclusions. Results: Out of 50 patients 22 (44.00%) patients had intracranial hemorrhage. Out of these 22 patients 9 (40.91%) had EDH, 9 (40.91%) had subdural, 2 (9.09%) had SAH and 2 (9.09%) had ICrH. Conclusion: This study demonstrates that the frequency of ICH is 44% and the incidence of SDH and EDH is equally higher than other types. Patients with RTA have higher risk of ICH and it is more in females than in males. Data analysis for different variables was done by using Microsoft excel 365. Graphs and charts were used to explain the results.

ABSTRACT
Abstract: As we herald into the 21st century, the quality of life and the repertoire of HAART (Highly active anti retro viral therapy) has considerably improved. However considerable work is still needed to educate the population about primary and secondary prevention modalities. Moreover regular monitoring of immune response with patients on HAART with conventional biomarkers is still a problem in low resource settings which needs to be addressed. We aim to review hsCRP as a potential biomarker in this regard.

ABSTRACT
Abstract: Regenerative therapies with platelet concentrate are used as they are physiological reservoirs of growth factors (FCs) and proteins, capable of accelerating tissue regeneration. The purpose of this work has been to evaluate the regenerative effect of allogenic platelet lysate through pathological findings in deep dermal burns. A cross-sectional, observational, descriptive study was carried out to determine the clinical effect of platelet lysate on tissue regeneration in 30 patients with deep dermal burns, in the Caumatology and Plastic Surgery Service, Hospital General "Dr. Juan Bruno ZayasAlfonso”, fromSantiago de Cuba, in the period from February 2013 to February 2014.The female sex prevailed in ages between 18 and 45 years, with the lower limbs standing out as the most affected region, in both groups of treatments. The application of platelet lysate favored healing and epithelialization in a shorter time than that described with conventional treatment, with minimal adverse events, without complications, achieving a better quality of the final. Histopathological findings showed that acts directly in the healing phases, stimulating early tissue regeneration.

ABSTRACT
Herpes zoster ophthalmicus (HZO) is a disease which occurs when the ophthalmic division of the trigeminal nerve is impaired as a result of reactivation of the varicella-zoster virus. Ophthalmic involvement has been considered the most important and potentially serious of all sites of Herpes Zoster virus. Objective of thispresent case study was to understand the modes of presentation and manifestations (ocular and extraocular) of HZO.This case study was conducted in the Outpatient Department of Ophthalmology at Indira Gandhi Medical College, Shimla (Himachal Pradesh). The Patient diagnosed with HZO was underwent a comprehensive ocular and extraocularexamination. The ocular manifestations of HZO in the Patient was acute vesicular, dermatomal ,painful, unilateral skin rash, hyperesthesia over his left forehead skin, Hutchinson sign present,Conjunctivitis in left eye with no exudates or obvious corneal scarring , Superficial punctate keratitis, stromal keratitis,Visual acuity Right eye-6/12, Left eye -6/18, IOP digitally normal bilaterally, Fundus cannot be assessed (CNBA) in the left affectedeye, normal ocular movements in all planes with no diplopia, normal direct and consensual pupillary reflexes. Patient was medically treated with antiviral, antibiotic, cycloplegic and other supportive drugs and followed up.

ABSTRACT
Necrotizing enterocolitis (NEC) is an acquired, multifactorial syndrome characterized by segmental, inflammatory, or ischemic necrosis of the small and large bowel. Although in adults the incidence of NEC is much lower and has lower mortality, the degree of morbidity remains high. As AMI may lead to fatal intestinal gangrene early diagnosis and treatment are paramount

ABSTRACT
As a resource constraint country, it was a difficult task to introduce percutaneous pulmonary valve implantation (PPVI) with MelodyTM. We aimed to see the outcome of our cases in this background. Retrospective analysis of six cases who had PPVI with MelodyTM in Combined Military Hospital, Bangladesh. Inclusion criteria were dysfunctional conduit between right ventricle (RV) and pulmonary artery causing (a) Symptoms of exceptional dyspnoea of various grade(NYHA II,III, IV) (b) RVEVD >150ml/m2+regurgitant fraction >40% (c) RVOT peak instantaneous gradient > 30 mm Hg. (d) RV dysfunction (RVEF<40%). Patient fulfilled above criteria were selected and outcome were analyzed. Mean age was 9 .56 + 2.96 years, weight was 28.75 + 8.61 kg, height was 137.5 + 17.52 cm. Mean age at surgery was 4.25+2.72 years. Female were 66.66%. Aortic homograft was used in 66.66 % cases. Eighteen mm Ensemble was used in four (66.66%) cases and 20mm and 22 mm in one each. Immediate result was excellent with no residual PS in two cases and negligible residual flow acceleration across pulmonary valve in four cases. No PR seen in all except one. One patient developed bacterial endocarditis after 3 years and was treated. Aim of PPVI is to prolong the life expectancy of conduits which were placed surgically from right ventricle to pulmonary artery. It significantly reduces the number of surgeries to change conduit in total life span of patient