The aim of the present communication was to describe characteristics of oro-facial clefts as well as oro-dental clefts’ sequel in new borns admitted in pediatric dentistry outpatient. The secondary endpoint was to expose contribution of pediatric dentist in the multidisciplinary management of oro-facial clefts and to propose a regular program of follow-up that have been recently adopted in our department of exercise. We performed a descriptive cross-sectional study between 2013 and 2020. Age at diagnosis, gender, type of cleft and other associated malformations were enrolled for all patients. Means and frequencies were calculated by Excell software. One hunderned and fourteen patients were enrolled. Diagnosis of clefts was made at birth in all patients. Newborns presented cleft lip in 0.88% ( n=1) , lip-palate in 41.2% (n=47), lip -palate -velar in 14.15 % (n=16), palate in 31% ( n=19), soft palate in 7.08% ( n=8) and hard and soft palate in 15% (n= 17). 9 % of newborns, admitted in our departement of exercise, had a follow-up. Malocclusions, (17%) / (n =20), were the most frequent sequeal observed in our cohort. Oro-facial clefts represent severe malformations requiering multidisciplinary support. Pediatric dentist must be implicated as soon as cleft diagnosis was made. His input helps reducing severe oral domages. His role is later extended to next stages of life in order to intercept and correct consequent malocclusion as early as possible.