Brain abscess has been considered a rare infection; it is characterized by a collection of pus in the brain parenchyma. Different studies talk about the management and medical treatment with antibiotic regimens (at the beginning of therapy, the antibiotic is chosen empirically), among the most used are vancomycin, third-generation cephalosporins, clindamycin, trimethoprim-sulfamethoxazole, aztreonam, metronidazole, fluoroquinolone, and fluconazole when it is a fungal-type infection, and linezolid has shown promising results. Surgical management depends on the size, location, and characteristics of the brain abscess; it is suggested in the literature for small brain abscess do the aspiration and eradicates the purulent material, and in a big abscess (> 2.5cm) performs craniotomy and resection. A decrease in the degree of mortality related to brain abscess has been reported. That is why this study is presented, carried out over three years (2018 -2021) showing the results obtained, as well as the frequency of patients with brain abscess treated in the service of neurosurgery, of the Regional Hospital “Lic. Adolfo López Mateos”, in Mexico City. A series of cases is presented showing the evaluation and diagnosis protocol used in Neurosurgery and the clinical-epidemiological characteristics that the patients gave.