ABSTRACT
Background: Inflammation denotes the body's standard physiological response to tissue damage. The injury may stem from physical or mechanical damage, trauma, autoimmune response, microbial invasion, or burns. Inflammation may be classified as either acute or chronic. Ziziphus jujube (ZJ), also known as Chinese date or Indian ber, is a widely researched medicinal plant due to its abundant phytochemical content, which may promote a healthy diet. It is a medium-sized indigenous plant belonging to the Rhamnaceae family. Ziziphus jujube (Z. jujube) is traditionally employed by locals to address dandruff, arthritis, chronic constipation, acne, antibacterial concerns, and cardiac ailments. Jujube comprises several constituents, such as flavonoids, triterpenic acids, amino acids, cerebrosides, mineral elements, phenolic acids, and polysaccharides. Aim: This study seeks to examine the effectiveness of Ziziphus jujuba flavonoid and terpenoid against COX-2 & 12- LOX to clarify their anti-inflammatory potential. Method: COX-2 & 12- LOX was chosen as the target proteins in the current investigation. The bond was found using the Auto Dock software using a grid-based docking method. Compounds' 2D structures were generated, converted to 3D, and subsequently energetically lowered up to an arms gradient of 0.01 using the Merck Molecular Force Field (MMFF). Result: Flavonoids (isoquercetrin) and terpenoid (zizyberanolic acid) of Z.jujuba effectively binds to be target protein COX-2 & 12-LOX respectively with binding energy -5.46 & -5.95 kcalmol-1 respectively. Conclusion: The finding of the in-silico molecular docking showed that both lead compound is effective binds & inhibitory action on target protein. The molecular docking outcome revealed that isoquercetrin binds COX2 whereas zizyberanolic acid binds 12-LOX, thereby suppressed the synthesis of PGs and ILs.

ABSTRACT
The present investigation compares the in vitro phytochemical composition and biological activities of extracts from Dalbergia oliveri and Lagerstroemia speciosa. Qualitative phytochemical screening confirmed the presence of various secondary metabolites, including alkaloids, flavonoids, tannins, saponins, and terpenoids in both extracts. Antibacterial evaluation against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa indicated that D. oliveri displayed superior inhibitory activity. Collectively, the results demonstrate that both plant species exhibit substantial phytochemical and bioactive potential, supporting their relevance in the development of natural antimicrobial therapies.

ABSTRACT
Anemia is a disease condition associated with reduced blood levels of red blood cells, hemoglobin, hematocrit and alteration other hematological indices, leading to decreased ability to transport oxygen in the body. It can be precipitated by many risk factors that may occur independently or concurrently. Tradomedicinal practice claims to treat anemia by use of herbal plants which are readily available, accessible and affordable when compared to pharmaceutical drugs. This work therefore sought to pharmacologically study the anti-anemic activity of a spice plant (Piper guineense) on phenylhydrazine-induced anemia in wistar rats. This was done by randomizing thirty adult male wistar rats into six groups (1-6) of five animals per group, measuring their hematological indices before (at day 0) and after (at day 7, 14 and 21) induction of anemia with phenylhydrazine (40 mg/kg, i.p.). Groups 1, 2 and 3 respectively served as normal, negative and positive control, while groups 4, 5 and 6 received Piper guineense leaf extract at 125, 250 and 500 mg/kg respectively. The results of this study shows that Piper guineense leaf extract particularly at medium and high doses, and with respect to negative control, ameliorates phenylhydrazine-induced alterations on hematological indices, by producing significant (p<0.05) lesser percentage decrease in blood levels red blood cells, hemoglobin and hematocrit, as well as exhibiting significant (p<0.05) lesser percentage increase in blood levels of other hematological indices analysed in this study. The results also indicate that Piper guineense leaf extract when compared to positive control, produces insignificant (p>0.05) activity, particularly at days 14 and 21. This study provides a robust scientific validation of tradomedicinal claim on Piper guineense leaf as anti-anemic agent, therefore recommends further studies that will unveil the bioactive principle(s) and the molecular mechanism/pathway responsible for the observed activity.