Fatigue is a natural signal given by the body due to a decrease in bodily functions caused work processes that will affect work capacity or endurance and it can reduce one's work productivity. The wood processing industry has various risks due to work environment factors around it. This study aimed to determine the Influence of Noise and Hot Work Climate on Fatigue Through Work Pulse on Workers of Production Division at PT. Maruki International Indonesia Makassar in 2019. This type of research was quantitative with a cross-sectional study design. The collection of 120 samples carried out using the Proportionate Stratified Random Sampling method. The Path Analysis test used to determine the direct and indirect factors of fatigue. The results showed that 17.5% of respondents experienced severe fatigue, the analysis test showed there was a direct effect of noise, hot work climate, and work pulse on fatigue (p = 0.000) meaning that if noise, hot work climate, work pulse increased by one point then fatigue increased, there is a direct effect of noise and hot work climate on work pulse (p = 0.000) meaning that if the noise and hot work climate has increased by one point, work pulse has increased, while the path analysis coefficient and hypothesis that there is an indirect effect between noise on fatigue through work pulse with indirect effect value of 0.795> from direct effect value of 0.795, there is an indirect effect between hot work climate on fatigue through work pulse with indirect effect value of 2.086> of direct effect value of 0.678. The company should provide standard personal protective equipment.