Technology facilities and health information system resources in the South Buru District Health Service have not been managed and developed efficiently due to the lack of supporting information infrastructure and the lack of supporting resources in managing the health information system. The purpose of this study was to determine the development of technology and health information system resources in supporting the achievement of Universal Health Coverage (UHC) in the South Buru District Health Office. This type of research is qualitative with a case study approach. The location of this research is the South Buru Health Service. Informants in this study are the heads of the Health Office, employees of the Office of Health Services, Information and Public Relations, and employees of the health information system/operator of the health information system, related fields, service provider operators, and the community. The research data collection techniques used in-depth interviews, document review and observation. The data obtained were analyzed using content analysis. The results showed that information system development facilities and technology and resource development in the South Buru District Health Service were still not well fulfilled, especially in remote areas of South Buru Regency. It is hoped that regional governments will pay more attention in developing health information systems in South Buru Regency.