EAS Publisher | Role of matrix- Metalloproteinases in the Pathogenesis of Periodontal Disease

Role of matrix- Metalloproteinases in the Pathogenesis of Periodontal Disease

DOI : https://doi.org/10.36349/easjdom.2020.v02i02.002

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Periodontal diseases are inﬂammatory disorders that give rise to tissue damage as a result of complex interaction between pathogenic microorganisms and host immune response. It is a term used to describe an inﬂammatory process initiated by plaque bioﬁlms that lead to loss of periodontal attachment to the root surface and adjacent alveolar bone, which ultimately results in tooth loss. Though microorganisms are the initiating agents, the disease initiation and progression are inﬂuenced by the host response being modiﬁed by environmental and behavioural factors. The disease progression involves a network of interacting molecular pathways made of pro-inﬂammatory mediators like cytokines, growth factors, reactive oxygen species, matrix metalloproteinases (MMPs), and their inhibitors and regulators.

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