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Role of matrix- Metalloproteinases in the Pathogenesis of Periodontal Disease

DOI : https://doi.org/10.36349/easjdom.2020.v02i02.002
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Periodontal diseases are inflammatory disorders that give rise to tissue damage as a result of complex interaction between pathogenic microorganisms and host immune response. It is a term used to describe an inflammatory process initiated by plaque biofilms that lead to loss of periodontal attachment to the root surface and adjacent alveolar bone, which ultimately results in tooth loss. Though microorganisms are the initiating agents, the disease initiation and progression are influenced by the host response being modified by environmental and behavioural factors. The disease progression involves a network of interacting molecular pathways made of pro-inflammatory mediators like cytokines, growth factors, reactive oxygen species, matrix metalloproteinases (MMPs), and their inhibitors and regulators.

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Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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