Objectives: The objective of this study was to evaluate the fluoride release and tensile strength of a heat cured denture base resin, which was surface treated with sodium fluoride. Methods: Total 40 rectangular specimens of poly methylmethacrylate (PMMA) resin were used in this study. Out of these, 20 resin specimens fabricated without sodium fluoride (NaF), were termed as group I, and remaining 20 specimens fabricated with 20wt% of NaF, termed as group II. All the specimens were stored individually in 10ml distilled water. From each of the specimens, 5ml water was taken to measure the fluoride release, at the time interval of 1hour, 1day and 3days. After 3days, the same specimens were used to measure the tensile strength.Results: There was maximum fluoride release at 1 hour and minimum at 3 days. Maximum decrease in fluoride release was observed between 1 hr and 3 days and minimum between 1 day and 3 day. All the three comparisons showed significant change (p<0.001).Conclusions: Heat-polymerizing denture base resin containing NaF filler releases significant amounts of fluoride and can act as a fluoride reservoir in the oral cavity.Clinical significance: There are numerous examples in dentistry where demineralization, or even frank caries, develops near or in association with restorative or prosthetic materials. A slow-release source of fluoride could help to prevent these problems and provide added protection throughout the mouth.