Hospitals are an important means of providing health services to the public. The purpose of this study was to determine how the quality of service affects the satisfaction of inpatients at the Madani Hospital in Palu. This study uses a quantitative method with a cross sectional study approach. Interviews were carried out on 205 of the entire inpatient population at the Madani Hospital in Palu. To find out how the quality of service affects the satisfaction of inpatients. Data was processed using chi square analysis and logistic regression. The results showed that the six variables studied based on Fisher's Exact Test results showed tangible (p = 0.003), reliability (p = 0.003), responsiveness (p = 0.006), insurance (p = 0,000), empathy (p = 0.006) and significantly influences the satisfaction of inpatients. Based on the results of the same logistic test, it was found that assurance with an expansive value (B) = 292,470 was the most influential variable on the satisfaction of inpatients. For the Madani General Hospital in order to further improve the quality of service, especially the responsive aspects and improve hospital management. With good management helps employees work in accordance with the hospital's vision and mission so that patient satisfaction becomes better.