Fatigue is a mechanism to protect the body from further damage so that recovery occurs after resting. Fatigue shows different conditions, but all of that results in a reduction in work capacity and endurance. The profession as a wood craftsman is exposed to various risks due to factors surrounding the work environment. This study aims to analyze the effect of dust exposure, age, work duration, on fatigue through respiratory disorder in workers at PT. Maruki International Indonesia Makassar. This research is quantitative, with a cross sectional study design, as well as a population of all wood craftsmen in the production section and a sample of 99 respondents. Sampling using proportional random sampling. To find out the direct and indirect factors of fatigue, path analysis is used. The results showed that there were 12.1% of respondents experiencing severe fatigue, the analysis test showed that there was a direct effect of work duration on respiratory disorder (p value = 0,000), age to respiratory disorder (p value = 0,000), age to fatigue (p value = 0,000) , while working period indirectly affects fatigue through respiratory disorder. However, there is no direct influence on the service life of fatigue, to the company to increase supervision regarding the use of standardized APD.