Vigna Unguiculata (cowpea) is a globally significant tropical legume valued for its high protein content, drought tolerance, and adaptability to marginal agro-climatic conditions. However, abiotic stresses, particularly soil salinization, severely constrain its productivity in arid and semi-arid regions. The RD22 (Responsive to Dehydration 22) gene family, encoding BURP domain-containing proteins, plays pivotal roles in regulating plant responses to abiotic stress, including salt and drought tolerance. This study presents an integrated bioinformatics pipeline to identify, characterize, and analyze putative salt stress-responsive RD22 genes in V. Unguiculata. Using Arabidopsis thaliana RD22 (UniProt: P22247) as a reference, we performed homology-based screening against the V. Unguiculata genome via Ensembl Plants BLAST. Candidate sequences underwent rigorous physicochemical profiling (ProtParam), conserved domain analysis (NCBI-CDD), motif elucidation (MEME Suite), phylogenetic reconstruction (MEGA), gene structure visualization (GSDS), and subcellular localization prediction (WoLF PSORT). Iterative filtering based on domain architecture and motif conservation yielded a high-confidence set of RD22 candidates. Phylogenetic analysis revealed diversification across the RD22-like subfamily, with evidence of legume-specific expansion. The majority of candidates exhibited predicted apoplastic and vacuolar localization, acidic to mildly basic isoelectric points, and thermostable aliphatic indices consistent with stress-responsive regulatory functions. Gene structural analysis revealed intron-exon architectural diversity, suggesting evolutionary divergence and potential alternative splicing regulation. This work establishes a foundational genomic framework for understanding RD22-mediated salt stress signaling in cowpea and identifies candidate targets for future functional validation and translational breeding toward salinity-tolerant cultivars.