Introduction: Acquired maxillofacial defects, most often of tumoral origin in West Africa, have major functional, aesthetic and psychological consequences. Maxillofacial prosthesis (MFP) remains the main rehabilitation option in Senegal, but local data on the lived experience of patients are scarce. The aim of this study was to assess satisfaction and the psychosocial impact of MFP in patients followed at IOS-UCAD. Methods: A descriptive cross-sectional study was conducted on 60 patients fitted with an MFP, recruited consecutively at the Prosthetics Department of IOS-UCAD in Dakar, from April to July 2025. Sociodemographic, clinical and prosthetic data, as well as satisfaction and psychosocial impact, were collected using a face-to-face questionnaire. Results: Mean age was 42.5 ± 18.8 years, with a female predominance (60.0%). The defect was of tumoral origin in 91.6% of patients. The MFP was maxillary in 90.0% of cases. Overall satisfaction reached 93.3%. Aesthetic (85.0%) and phonatory (85.0%) satisfaction was high; masticatory function remained the lowest-rated dimension. The patient–caregiver relationship was rated fully satisfactory by all patients on the five criteria assessed (100.0%). The psychosocial impact was positive: 96.7% of patients reported feeling at ease with themselves and having regained self-confidence; 93.3% reported improved social integration. Conclusion: MFP provides a rehabilitation considered satisfactory by the great majority of Senegalese patients and restores a quality of life compatible with social reintegration. Masticatory satisfaction is the main area for improvement. The expansion of MFP services within the Senegalese hospital network should be strengthened.