EAS Publisher | Cerebral Thrombosis due to « Protein S

Cerebral Thrombosis due to « Protein S » Deficiency: About a Case

DOI : https://doi.org/10.36349/easjacc.2026.v08i03.004

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Thrombosis of the dural venous sinus or cerebral veins is a complete or partial occlusion that can affect one or more main sinuses. Involvement of the feeding cortical veins can lead to heterogeneous manifestations (headaches, altered consciousness, behavioral abnormalities, convulsions, speech difficulties and focal or generalized neurological deficits). The incidence of CVT is estimated at 5 per 1million. Venous thromboembolism [TE] is a multifactorial disease, and protein S deficiency [PSD] constitutes a major risk factor. Treatment of CVT with Heparin followed by VKA is recommended by current guidelines and should be started as soon as the diagnosis of CVT is confirmed we will report the case of a 17-year-old male with a medical history of anemia that was admitted in our ICU ward for a cerebral veinous thrombosis complicated with thrombo-embolic pattern. The initial treatment of TE followed the treatment guidelines of the American society of stroke. However, there are no guidelines of long-term treatment in children with PS deficiency. The actual recommendations didn’t state the best moment to introduce an anticoagulant.

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