This study investigates the psychological profile of self-actualized Palestinian entrepreneurial women through an in-depth case study approach. The research addresses a critical gap in understanding the intersection between entrepreneurship, psychological resilience, and self-actualization within conflict-affected contexts such as the Gaza Strip. Drawing on clinical and qualitative methodologies, the study integrates projective and structured assessment tools, including the Thematic Apperception Test (TAT), self-actualization scales, problem-solving measures, optimism, risk-taking tendencies, social power orientation, and moral reasoning assessments. The findings reveal that self-actualized entrepreneurial women exhibit a complex psychological structure characterized by high levels of intrinsic motivation, adaptive problem-solving strategies, cognitive flexibility, and a strong sense of purpose aligned with both personal and collective goals. Despite exposure to socio-political constraints and economic instability, participants demonstrated resilience patterns supported by optimism, internal locus of control, and moral commitment. Notably, the interaction between self-actualization and entrepreneurial traits appears to be mediated by contextual adversity, transforming external constraints into drivers of psychological growth and innovation. The study contributes to the literature by offering a context-sensitive psychological model of female entrepreneurship in marginalized environments, emphasizing the role of internal psychological resources in achieving self-actualization. The findings have practical implications for psychological counseling, entrepreneurship development programs, and gender-focused empowerment policies in similar socio-cultural contexts.