Fibroid is a reproductive health problem which affects females of reproductive age in all parts of the world. Various health implications associated with fibroid which ranges from miscarriages, infertility etc. The aim of the study is to investigate the effects of ethanolic extract of cocoa seeds on monosodium glutamate induced uterine fibroids in wistar rats. Forty eight (48) animals were used for the study. Animals were grouped into six(6) groups (control, fibroid induced, cocoa low, cocoa high, low dose+ MSG, high dose+ MSG group, MSG + high dose group and MSG + low dose) of 6 animals each. Extracts were administered for 14days, Control received 0.5 ml of distilled water; Fibroid induced received 200mg/kg bw of MSG; cocoa low group received 500mg/kg bw; cocoa high group received 1500mg/kg bw; cocoa low group +MSG received 500mg/kg bw+200mg/kg bw of MSG.; cocoa high group +MSG received 1500mg/kg bw + 200mg/kg bw of MSG, MSG + low dose group MSG was administered for 2 weeks, followed by 500mg/kg body weight of cocoa for 2 weeks. MSG + high dose group MSG was administered for weeks, followed by 1500mg/kg body weight of cocoa for 2 weeks. 24 hours after last administration animals were sacrificed. Blood samples were collected for hormonal assays. The uterus was harvested and fixed. Data obtained was expressed at Mean ± Standard deviation, values were considered statistically significant when p≤0.05. The results showed that ethanolic extract of cocoa seeds reduced the level of progesterone in the prophylactic groups when compared to the fibroid induced group. Results from the therapeutic studies showed that ethanolic extract of Cocoa seed reduced the level of progesterone only. It had no effect on the estrogen level of Wistar rats. The plant extract may arrest tumor progression and may be effective in prevention of MSG induced uterine fibroids in rats.