Background: Histologically, fibroids are disordered smooth muscle cells buried in abundant quantities of extracellular matrix. The abundance of extracellular matrix in fibroids is responsible for the expansion of fibroids. Uterine fibroids are benign neoplasms. Materials and Method: Adult female Wistar albino rats (200 ± 20g) were used for the present study. Animals were acclimatized for fourteen days in the animal house before being grouped into four groups of six (6) animals each. The eight experimental groups are as follows: Group A: No fibroid induction, animals were provided with water and normal rat fed; Group B: Uterine fibroid induced without treatment; Group C:(treatment group): Mifepristone; Group D : (treatment group): Uterine fibroid induced+ Mifepristone; Group E:(treatment group): Uterine fibroid induced+ 500 mg/kg of extract ; Group F:(treatment group): Uterine fibroid induced+ 1500 mg/kg of extract; Group G:(treatment group): 500 mg/kg of extract; Group H:(treatment group): 1500 mg/kg of extract. Uterine fibroid was induced by administering Diethylstilbestrol (1.35 mg/kg/d), Progesterone injection of 1.0mg/180g intramuscularly three times a week, 0.9 mg/kg/d adrenal hydrochloride injection intramuscularly from week 5th to 6th week of the experiment (Zhao et al., 2018 method). Uterine fibroid induction lasted for six (6) weeks. Results: Results from the present study showed that estrogen and progesterone both increased in fibroid induced group when compared to the control, and both reduced in the treatment groups especially in the high dose group when compared to the fibroid induced group. Immunohistochemical studies showed weak positive stain for BCL-2 and strong positive stain for BAX in the ovaries. Weak positive stain for BCL-2 and strong positive stain for BAX in the uterus was also observed. Conclusion: Bay leaves significantly reduced the levels of estrogen and progesterone caused by induced uterine fibroids. Bay leaves may likely reduce the si