Uterine fibroids (also called leiomyomas) are benign growths made of the uterine smooth muscle. It is a common problem that causes significant health issues in women of reproductive age. Monosodium Glutamate (MSG), a sodium salt of glutamine acid, found in processed foods like instant noodles, canned meats, etc. Breadfruit (Artocarpus altilis) a fruit with numerous benefits, which is rich in nutrients, fiber, anti-inflammatory properties, anti-microbial properties, and rich in anti-oxidants. Forty-eight (48) animals were used for this study. The animals weighed 120 ± 20g. Animals were grouped into eight (8) groups: Control group- received 0.5mls of distilled water orally for 2 weeks; Fibroid Induced group- received 200mg/kg of MSG intraperitoneally for 2 weeks; Breadfruit low dose group- received 500mg/kg of breadfruit extract orally for 2 weeks; Breadfruit high dose group- received 1500mg/kg of breadfruit extract orally for 2 weeks; MSG + Low dose group- received 200mg/kg of MSG intraperitoneally for 2 weeks + 500mg/kg of breadfruit extract orally for 2 weeks; MSG + High dose group- received 200mg/kg of MSG intraperitoneally for 2 weeks +1500mg/kg of breadfruit extract orally for 2 weeks; Low dose + MSG group- received 500mg/kg of breadfruit extract orally for 2 weeks + 200mg/kg of MSG intraperitoneally for 2 weeks; High dose + MSG group- received 1500mg/kg of breadfruit extract orally for 2 weeks +200mg/kg of MSG intraperitoneally for 2 weeks. The animals were sacrificed 24 hours after the last administration using chloroform. Blood samples were collected for hormonal assay. The uterus was harvested and fixed. Data obtained was expressed as mean ± SD, values were considered statistically significant when P≤0.05. From the therapeutic study, the results showed that the extract reduced the estrogen and progesterone level. From the prophylactic study, the results showed that the estrogen level reduced significantly. Statistically significant difference was not observe