Introduction: The Sub-Saharan African population is experiencing an increase in neurodegenerative diseases (ND). Parkinson’s disease (PD) is one of the major ND encountered due to a steady increase in life expectancy. We aimed to determine the prevalence, describe the clinical characteristics, and the most common comorbidities of patients with PD. Methods: A descriptive cross-sectional study was carried out at the neurology outpatient department of the Yaoundé Central Hospital (YCH). Sociodemographic, clinical data and paraclinical data were obtained after informed consent. Moreover, the UK Parkinson’s Disease Society Brain Bank Diagnostic Criteria (UKPDSB) was used for diagnosis, and the Movement Disorders Society Unified Parkinson’s disease Rating Scale (MDS-UPDRS) was used to assess severity and disease progression. Results: Out of a total of 725 patients consulted at the YCH, PD accounted for a hospital-based prevalence of 4.27%. Bradykinesia and rest tremor were the most common presenting motor symptoms (96.77% each), followed by cogwheel rigidity (58.06%) and postural instability (22.58%). Non-motor symptoms were fatigue (64.52%), autonomic dysfunctions with cardiovascular disorders [orthostatic hypertension (64.52%)], gastrointestinal disorders [constipation (41.94%)], and urinary problems (38.71%). Hypertension was found to be the most common comorbidity in the study population (35,48%). Conclusion: The hospital prevalence of PD is not negligible and remains one of the most frequent ND in SSA.