The study of the foot print which is known as plantar dermatoglyphics has been in existence for decades. Like fingerprints, no two persons have the same footprints. The study aimed at determining the plantar dermatoglyphics of Down’s syndrome and healthy subjects of Nigeria. The study comprised of 201subjects, 101 (58 males and 43 females) Down syndrome and 100 (65 males, 35 females) control subjects. The study was conveniently carried out in some special schools in Lagos, Abuja and Port Harcourt. The healthy subjects were gotten from University of Port Harcourt Demonstration Secondary School. The subjects were selected using a scanning method according to Oghenemavwe & Osaat (2015) and chi-square test was used to analyzed the sole of the foot and the big toe. The results revealed significant differences between Down’s syndrome subjects and control subjects in zone I to IV (right hand) and I to III, V (left hand) for both sexes and the big toe bilaterally. Down’s syndrome had increased frequency of distal and proximal loop on zones I and II respectively (p<0.05), increased frequency of open field on zones I to III (p<0.05). However, a significant increase was observed in whorl for control subjects when compared to Down’s syndrome subjects (p<0.05). The difference across the pattern in the big toe between Down’s syndrome and control subjects was significant with Down’s syndrome having more of whorl than control subjects (p<0.05). The study suggested plantar dermatoglyphics a supportive method that could be useful in screening Down’s syndrome for early intervention.