Introduction: Treatment of locally advanced cervical cancer requires the use of radiotherapy. The tumour response rate measured midway through radiotherapy provides valuable prognostic information. This study sought to document the dose distribution and early tumor response in patients treated with cobalt teletherapy at Cancer Diseases Hospital (CDH). The objective was to determine the effectiveness of Cobalt Teletherapy in the treatment of cervical cancer patients at CDH with an anteroposterior separation of 21 cm and above using the four-field technique. Methodology: The study employed a cross-sectional design. Population was patient treatment files. All files fitting the criteria were included. Dose distribution and treatment response assessment data was retrieved and analysed. Descriptive and inferential statistics were run for the analysis. Results: There was a significant association between tumour size, the level of haemoglobin, and the number of fractions received during External Beam Radiotherapy (EBRT) (p<0.001), before and after treatment. An increase in the number of fractions received during EBRT and an increase in the level of haemoglobin resulted in the tumour size reduction. No significant association was seen between tumour size and Anterior Posterior (AP) separation, Age, Dose to the 95% isodose line (p>0.05). Other factors not significantly associated with tumour size reduction include Parity HIV status, Performance status, Average radiation dose, field size, number of chemotherapy circles, chemotherapy type. Conclusion: There is contextual evidence that tumour can reduce in size with an increase in number of fractions received during EBRT and level of haemoglobin. AP separation, Age, Parity, HIV status, Performance status, Average radiation dose, field size, number of chemotherapy circles, chemotherapy type, and Dose to the 95% isodose line did not show any effect on cervical tumour size (p>0.05).