This study evaluated the effect of the administrations of ethanol extract of Pterocarpus erinaceus leaves and potassium bromate respectively and in combination on serum electrolytes, total protein, lipid profile and haematological parameters in albino rats. The experimental animals were divided into four groups: Group A (control) was administered water, group B were administered 200 mg/kg potassium bromate, group C were administered 200 mg/kg P. erinaceus extract and group D were administered a combined dose of 200 mg/kg potassium bromate and 200 mg/kg of P. erinaceus extract, all the administrations were done orally and continued daily for 21 days. It was observed in this study that potassium bromate decreased bicarbonate ion in the serum while the administration of P. erinaceus extract alone and in combination with potassium bromate increased bicarbonate ion in the serum. Rats administered with potassium bromate exhibited slight symptoms of toxicity while the Pterocarpus erinaceus leave extract showed a strong preventive effect against some biomarkers of cardiovascular damage. Groups administered the combined dose of potassium bromate and the extract showed a uniform percentage increase in white blood cell, lymphocytes, hemoglobin, hematocrit, mean corpuscular volume accompanied by a decrease in red blood cells and platelet. The research reaffirmed the negative food safety impact associated with the consumption of potassium bromate, the ameliorative effect of the ethanol extract of P. erinaceus and its potential in preventing cardiovascular diseases.