Sexual-performance–enhancing products (aphrodisiacs) are widely used, yet their chronic and combined consumption may pose renal risks because the kidneys are central to drug metabolism and excretion. In Nigeria, concurrent use of prescription agents (e.g., sildenafil), herbal extracts (e.g., Trigonella foenum-graecum), and alcoholic bitters is common, but comparative experimental evidence on renal safety is limited. This study aimed to compare the effects of sildenafil citrate, aqueous T. foenum-graecum seed extract, and a selected alcoholic bitters—alone and in combination—on renal function in male Wistar rats. A randomized controlled experimental design was used: forty adult male rats were allocated into eight groups (control; low/high fenugreek; low/high sildenafil; low/high bitters; and combined low-dose of all test substances) and treated orally once daily for six weeks. Renal function indices (electrolytes/acid–base indices, urea, creatinine) were assessed, kidneys were examined histologically, and data were analysed using one-way ANOVA with Tukey’s HSD post hoc test (α = 0.05). There were significant between-group differences in bicarbonate (F(7,32) = 7.712, p = 0.000), sodium (F(7,32) = 6.071, p = 0.000), and urea (F(7,32) = 6.849, p = 0.000). Pairwise comparisons showed significant differences involving the control group for bicarbonate (most pairings, p < 0.05), and significant sodium differences including high-dose bitters versus several groups (e.g., Group 6 vs Group 8, p = 0.000). Creatinine differed significantly across multiple treated groups versus control (e.g., control vs Groups 3–6, p ≤ 0.038). Histology showed dose-related renal injury, with alcoholic bitters demonstrating the most pronounced lesions (glomerulonephritis and myxoid degeneration), while fenugreek and sildenafil produced milder-to-moderate tubular/glomerular alterations. In conclusion, repeated exposure to these aphrodisiacs produced treatment- and dose-dependent renal dysfunction a