Introduction: Hypertension is a non-communicable disease with a rising global prevalence. In Indonesia, particularly NTT which ranks fourth with 76,130 cases, hypertension remains a significant health problem. The Chronic Disease Management Program (Prolanis) by The Social Security Organizing Agency (BPJS) aims to manage and control chronic diseases, including hypertension. Aims: To know the effect of compliance following Chronic Disease Management Program (Prolanis) on the blood pressure condition of hypertensive patients at the Sikumana Health Center. Method: Observational analytics with cross sectional (cut latitude) research design. This research's primary data were taken from interviews and filling out The Five-Item Medication Adherence Report Scale (MARS-5) questionnaire, while secondary data were collected from respondents' medical records. The number of respondents who met the research’s criteria was 15 respondents. Results: The majority of respondents were aged 59–65 years (13 participants; 87%) and female (13 participants; 87%). Adherence to the Prolanis program was observed in 10 participants (67%), while 5 participants (33%) were non-adherent. Stable blood pressure was identified in 10 participants (67%), whereas 5 participants (33%) exhibited unstable blood pressure. Statistical analysis demonstrated a statistically significant and strong association between variables (p < 0.05; r = 0.707). Conclusion: There is a significant influence of compliance following Prolanis on the blood pressure condition of hypertensive patients in the Sikumana Health Center.