Hormonal Contraceptives are a widely used contraceptives methods for the prevention of pregnancy in women. It is associated with changes in Renal Biomarkers which results in chronic kidney disease, glomerular disease, hydronephrosis, Bilateral Pylonephtritis and Hypertention which are the major cause of premature death. We aim to determined renal markers changes In relation to duration of Injectable, Implanon and oral Contraceptives. A cross sectional case control study design was conducted on 225 hormonal contraceptive users and 225 women not on contraceptives (controls) serum levels of Urea, Creatinine, Uric acid were analyzed using standard enzymatic and calorimetric assay while Micro albumin was measured using immunoturbidimetric methord. Data generated were analyzed using Statistical Package for Social Sciences (SPSS) version 23, and it was manufactured by IBM Corporation from United States in 2015. The level of statistical significant was set at p<0.05, T-test was used to compare means of two groups and one way Anova was used to compare means of more than two group followed by Duncan multiple range, which post-hoc test was also used to figure out exactly which group are different from each other. The women received injectable hormonal contraceptives there were not significantly (P>0.05) higher in urea and uric acid levels when compared with Implanon and significantly (P<0.05). Lower to those used oral contraceptives. All the contraceptives had not-significant effect on serum, urea and uric acid (F=7.912, P=0.001) (F=5.040. P=0.009). The women received injectable hormonal contraceptives were not significantly (P>0.05) higher in Creatinine, micro Albumin levels when compared with Implanon and not significantly (P>0.05) lower to those used oral contraceptives. All the contraceptives had not significant effect on Serum Creatinine and Micro albumin (F=0.001, P=0.999) (F=0.344, P=0.710) with Implanon having the least effect. Hormonal contraceptive are influenced by