Carotid artery lesions are a major cause of ischemic stroke. General anesthesia for carotid endarterectomy requires costly neurological monitoring, which is often unavailable in certain settings, such as that of this study. This work evaluates the feasibility and benefit of ultrasound-guided regional anesthesia (RA) combining intermediate and superficial cervical plexus blocks. This was a prospective descriptive study conducted over 13 months, including 9 patients. The RA technique, under ultrasound guidance, combined a pericarotidial infiltration, an intermediate cervical block, and a superficial block with cutaneous infiltration, using 0.5% bupivacaine. The primary endpoint was the quality of the sensory block. RA was complete in 89% of the tested territories. Additional sedation-analgesia was required for 3 patients (33%). No serious complications occurred. Minor adverse effects (cough, hoarseness) were transient. Postoperative analgesia was satisfactory. In conclusion, this combined ultrasound-guided block is a viable and safe alternative to general anesthesia for carotid surgery in resource-limited settings, allowing for continuous clinical neurological monitoring. The choice of technique should be individualized.