Hepatic fasciolosis is a gastrointestinal helminthiasis caused by a parasite of the genus Fasciola that severely impacts the health of animals and humans, and for which direct diagnosis remains ineffective. The study was conducted from January to July 2023 on 400 cattle from municipal slaughterhouses in the city of Ngaoundere to determine the effectiveness of screening for bovine fascioliasis using the Mini-FLOTAC test. The results showed a prevalence of 25.25% in the Mini-FLOTAC test, which is significantly lower (p<0.001) than that obtained in bile examination (67%), liver autopsy (46.50%) and coprology (30.75%). The parasite densities of infested animals, which vary significantly between 10.72±1.6 flukes for liver autopsy and 688.6±10.7 eggs for bile examination (F=101.751; ddl=3; p=0.002), show no significant difference between that obtained in faecal sedimentation (254) and in the Mini-FLOTAC test (11.82) (p>0.05). Infestation levels varied between 1.8% and 79.8% for sedimentation coprology, 9.5% and 90.5% for Mini-FLOTAC flotation coprology, 3.2% and 78% for liver autopsy, and 5.8% and 50.8% for bile examination are significantly low (p>0.05). The sensitivity of coprology using the Mini-FLOTAC test, estimated at 37.68%, is significantly lower than that of coprology using sedimentation (45.89%) (p<0.05). The Mini-FLOTAC test is therefore less sensitive for screening for fasciolosis than sedimentation coprology.