Cryptosporidiosis is a cosmopolitan food and waterborne zoonosis responsible for severe diarrhea in young animals, newborns, and immunocompromised individuals. This study was conducted from January to June 2023 in the Vina division to determine the epidemiology of the disease in calves. The search for Cryptosporidium spp oocysts in feces was conducted using the modified Ziehl-Neelsen staining technique. Out of 405 fecal samples examined, 270 tested positive, giving an overall prevalence of 66.67%. This prevalence is very significantly higher in calves aged [0-3[months (48.1%) compared to those aged [3-6[months (29.9%) and [6-12] months (29.6%) (P=0.008). It is higher during the rainy season (40%) (P=0.004), in the Nyambaka (48.3%) and Mbe (41.7%) districts (P=0.008), in diarrheic calves (99.13%) (P=0.01), in NEC= [0-2] (38.7%) (P=0.008), and in those weighing less than 40 kg (88.9%) (P=0.001). The established risk factors are the season, the locality, the age, and the diarrheal status. These results show that the infestation of Cryptosporidium spp in the Vina department is present and significant, highlighting the urgency to improve the health and hygiene system in farms to prevent human infections.