Cotton cultivation in Cameroun is characterized by low yields due to soil infertility and pest infestation. Sustainable improvement requires the use of mycorrhizae combined with aqueous extracts from Hyptis suaveolens and Cyperus rotundus rhizomes. The experimental design used is 7×2×2 split-plot with to factors and seven treatments: (control (Te-); chemical input (Te+); H. suaveolens (H); C. rotundus (C); mycorrhizae (M); two combinations: mycorrhizae-H. suaveolens (M+H) and mycorrhizae-C. rotundus (M+C); two varieties (Q302 and L457) and two localities (Kodek and Mouda). The treatments M+H, M+C, mycorrhizae (M), aqueous extracts of H. suaveolens and C. rotundus (C) improved cotton yield by 30,91; 29,66; 26,34; 9,96 and 7,01 % respectively compared to the Te- treatment. Similarly, the Te+, M+H, M+C, mycorrhizae (M), H. suaveolens extract (H) and C. rotundus extract (C) treatment improved cotton seed yield by 26,14; 26,67; 22,25; 18,04; 14,84 and 10,08 % compared to the Te- treatment. Overall, there were no significant differences between plots treated with the combination of mycorrhizae and aqueous extracts of H. suaveolens or C. rotundus could be an alternative to the use of chemical inputs in order to improve cotton productivity in the Far North Region of Cameroon while ensuring sustainable agriculture.