EAS Publisher | The Contribution of Next-Generation Sequencing (NGS) in the Diagnosis of Fungal Infections without Culture: Metagenomics Applied to Clinical Mycology

The Contribution of Next-Generation Sequencing (NGS) in the Diagnosis of Fungal Infections without Culture: Metagenomics Applied to Clinical Mycology

DOI : https://doi.org/10.36349/easjpid.2025.v07i04.006

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Fungal infections have emerged as a significant global health concern, particularly among immunocompromised individuals, where they can lead to severe morbidity and mortality. Traditional diagnostic methods, primarily reliant on culture techniques, often fall short due to their lengthy turnaround times and inability to detect non-viable or fastidious organisms. Next-Generation Sequencing (NGS) has revolutionized the diagnostic landscape by enabling rapid and comprehensive identification of fungal pathogens directly from clinical specimens without the need for culture. This article explores the principles of NGS, its applications in clinical mycology, and its potential to enhance diagnostic accuracy and treatment outcomes. By leveraging metagenomic approaches, NGS facilitates the detection of mixed infections, antifungal resistance profiling, and real-time monitoring of disease progression. Despite its challenges, including cost and the need for bioinformatics expertise, NGS represents a paradigm shift in the diagnosis of fungal infections, paving the way for improved patient management and outcomes.

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