Objective: The aim of this study was to investigate the clinical profile and therapeutic aspects of traumatic brain injuries in the intensive care unit. Patients and Methods: We conducted a retrospective and descriptive study over a period of January 2021 to December 2023 (24 months) in the multi-purpose intensive care unit of Thierno Birahim Ndao Hospital in Kaffrine, Senegal. The study involved analyzing the medical records of patients admitted for isolated or combined traumatic brain injury. The parameters studied were epidemiological and clinical data, treatments administered, and patient outcomes. Results: During our study period, 38 patients presented with traumatic brain injury, representing a frequency of 5.20% of hospitalizations. The mean age of the patients was 27 years (range 4-65 years), with a male-to-female ratio of 8.5. Road traffic accidents were the major cause of the injuries (86.84%). Patient transport was medically supervised in 10.52% of cases. In our study, 12 patients (31.57%) had a Glasgow Coma Scale (GCS) score of 8 or lower. Traumatic brain injury was associated with chest trauma in 26.31% of cases. All patients underwent brain and cervical computed tomography (CT) scans. Mechanical ventilation and sedation were administered in 39.47% of cases. Eighteen patients (47.36%) received osmotic therapy with mannitol (20%). The mortality rate was 40.3%. Conclusion: Traumatic brain injury is serious, especially when associated with deep coma and chest trauma. The prognosis can be improved with good organization and adequate facilities for patient care.