Introduction: The anesthetic strategy for esophageal surgery has evolved thanks to optimization of patient care from the preoperative phase to postoperative rehabilitation. The objective of this study was to describe the anesthetic management of esophagectomies for esophageal cancer at the Aristide Le Dantec University Hospital. Patients and Methods: We conducted a retrospective and descriptive study from January 2014 to December 2021. We included all patients who underwent anesthesia for esophagectomy for esophageal cancer. We studied the epidemiology, the anesthetic technique, analgesia and postoperative complications. Results: We collected data on 18 patients with a mean age of 45 years and a male-to-female ratio of 0.63. Patients were classified as ASA I (American Society of Anesthesiologists) in 27.77%, ASA II in 56.66% and ASA III in 16.66% of cases. General anesthesia was combined with epidural analgesia in 61.11% of cases. Intraoperative analgesia was maintained with fentanyl in 11 patients. The mean intraoperative blood loss was 150 ml. The mean duration of surgery was 3 hours and 40 minutes (range: 2 hours and 50 minutes to 6 hours and 30 minutes). The predominant postoperative analgesia protocol was a combination of paracetamol, nefopam and epidural analgesia. Postoperative morbidity was 50%, and postoperative mortality was 16.66%. Conclusion: Perioperative management of this surgical procedure through good preoperative assessment improves patient prognosis.