Background: Postoperative infections in orthopedic implants remain a challenging complication, contributing to morbidity, prolonged hospitalization, and healthcare costs in low-resource settings. This study aimed to determine the epidemiological profile, bacterial isolates, antibiotic susceptibility patterns, and treatment outcomes of postoperative infections following orthopedic implant surgeries in Bangladesh. Methods: This prospective cohort study was conducted at the District Sadar Hospital, Rajbari, Bangladesh, from May 2023 to April 2024. A total of 280 patients with confirmed postoperative implant infections were analyzed. Demographic data, infection timing, bacterial isolates, antibiotic sensitivity, and treatment outcomes were also recorded. Data were analyzed using SPSS version 25.0. Results: The mean age of the patients was 45.6 ± 15.2 years, with 70% males. Early onset infection occurred in 44.3% of the cases. Staphylococcus aureus (38.6%) was the predominant isolate, and it showed high sensitivity to vancomycin and linezolid. Debridement with implant retention achieved infection control in 81.2% of cases, whereas implant removal and revision had the best eradication rates (87%). Conclusion: Postoperative infections in orthopedic implants are primarily early onset and dominated by gram-positive cocci. Effective surgical debridement combined with appropriate antibiotics remains the cornerstone of treatment. Enhanced infection control and antibiotic stewardship are crucial for reducing the incidence and resistance patterns.