Counties mitigate the virus through interventions like home isolation and social distance affected economic downward. So far no treatment or vaccine has been conformed, making people in depressed and anxious physiological mind state from catching the virus themselves or their beloved ones. Also, with number of infected individuals are rising, the health system is becoming overwhelmed. Preventing the disease and preventing its occurrence by taking a prophylaxis has a great effect in reducing the negative consequences of this disease, including huge human and economic losses, even on the psychological level, and reducing the isolation period. Glycyrrhizin acid is the main active component of Licorice root which has been known in traditional Chinese and Japanese medicine since ancient times. In these cultures, glycyrrhizin acid (GA) is one of the most frequently used drugs. The potential of GA to prevent or control the disease caused by this disease primarily from its ability to inhibit the enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). the consumption of GA has various benefits including antiviral, anti-inflammatory, antioxidant and immunomodulation effect. In this review we propose Glycyrrhizic acid as a potential cost-effective botanical drug for pandemic SARS-COV-2 infection prophylaxis.