The prevalence rates of hepatic and renal conditions have become global burden as they are significantly influenced by changing lifestyles/occupational engagements, etc. Thus, the present study investigated the alterations of some hepatic/renal markers and serum heavy metals levels in automobile artisans in Port Harcourt. The study adopted the purposive/snowball sample size selection methods in recruiting participants. A total of 100 volunteers were surveyed for the study, comprising 60 automobile repair artisans and 40 non-automobile artisans. Data from the study were subjected to statistical analyses using the appropriate tools of the IBM Statistical Product and Service Solutions (SPSS) version 25.0. The auto spray painters, blacksmiths and electricians had significantly (p<0.05) raised levels of chromium level when compared to those of the controls (non-auto artisans), auto mechanics, welders and panel beaters. The levels of lead (Pb) in all other sub-groups of the auto-artisans, aside from the auto-mechanics, were significantly raised (p<0.05) when compared to the mean value of the control subjects. The Cd level in the blacksmith were significantly higher when compared to all other groups including that of the control group. For the creatinine levels, all the sub-groups of the auto-artisans had significant (p<0.05) increases in their levels when compared to that of the non-automobile artisans (control) and the inverse of the foregoing occurred in the eGFR, only that that of the mechanics were excluded. The present study found a significantly raised alkaline phosphatase (ALP) level in the blacksmiths when compared to that of all other groups. The aspartate transaminase (AST) and alanine transaminase (ALT) levels in all artisans had significantly raised levels when compared to the respective mean values of the control group. In conclusion, the tendency for the development of CKD and liver-conditions amongst the auto-artisans may be sufficiently connected with occu