The paper investigated the nexus between job design and employee work outcomes as well as the mediating roles of employee commitment and job satisfaction of Deposit Money Banks in Enugu Metropolis The study adopted quantitative survey design and this allowed for the collection of data from a large number of respondents. The population of the study was 386 employees from Deposit Money Banks. The sample size was determined using Yamane sample size determination formula and a sample of 201 employees was selected through a stratified sampling procedure. Data were collected, using a structured questionnaire designed on a 5-point Likert scale. The validity of the data collection instrument was determined through content validity approach. The data collected were analysed through the application of one step process approach of Patial Least Square Structural Equation Modelling (PLS-SEM) with the aid of Smart PLS software 4.1.2 version. The results demonstrated that job rotation has a positive significant effect on employee commitment (β= 0.268, t= 9.25, P< 0.05). There was a positive significant relationship between job enrichment and job satisfaction. (β = 0.342 t= 9.71, P< 0.05), There was a negative but significant relationship between job satisfaction and employee productivity ( β= -0.060 t= 3.734, P< 0.05), In terms of the indirect relationships, employee commitment mediated the relationship between job rotation and employee productivity (β= -0.159, t= 6.390, P <0.05) and job satisfaction mediated the relationship between job enrichment and employee productivity (β= 0.405, t= 8.409, P <0.05). We recommended that the approaches of job design should be executed to foster job satisfaction, employee commitment, employee productivity and motivation of workers in Deposit Money Banks in Nigeria.