EAS Publisher | Effect of Hugonia Mystax Leaves on Physical and Biochemical Parameters in Ethanol Induced Liver Damage in Rats

Effect of Hugonia Mystax Leaves on Physical and Biochemical Parameters in Ethanol Induced Liver Damage in Rats

DOI : https://doi.org/10.36349/easjpp.2019.v01i06.006

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The present investigation was aimed to evaluate hepatoprotective effects of ethanol extract of leaves of Hugonia mystax (HMEE) against ethanol induced hepatotoxicity in rats. The HMEE at the doses of 200 and 400 mg/kg and silymarin 100 mg/kg were administered to the ethanol challenged rats. The effect of HMEE and silymarin on physical (wet liver weight, liver volume) and biochemical parameters (SGOT, SGPT, ALP, direct and total Bilirubin) were measured in ethanol induced hepatotoxicity in rats. Treatment with HMEE (200mg/kg and 400mg/kg) reduced the elevated levels of above mentioned physical parameters and biochemical markers of hepatotoxicity. The hepatoprotective properties may be attributed to the polyphenolic compounds like flavonoids, saponins and tannins that are present in the HMEE.

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