EAS Publisher | Effects of Copper Oxide and/or Zinc Oxide Nanoparticles on Oxidative Damage and Antioxidant Defense System in Male Albino Rats

Effects of Copper Oxide and/or Zinc Oxide Nanoparticles on Oxidative Damage and Antioxidant Defense System in Male Albino Rats

DOI : https://doi.org/10.36349/easjpp.2019.v01i06.002

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Background: Oxidative stress is one of several mechanisms leading to nanotoxicity. Some nano-metal oxides can enhance ROS generation, inducing oxidative stress, DNA damage, and unregulated cell signaling, and eventually leading to changes in cell motility, apoptosis, and even carcinogenesis. The level of ROS generation by engineered nanomaterials is dependent on the chemical nature of the nanoparticles. Antioxidants play an important role in preventing, or in most cases, limiting the damage caused by ROS. Objectives: The aim of the present study was to evaluate the effects of copper oxide and/or zinc oxide nanoparticles on oxidative damage and antioxidant defense system in male albino rats.

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