EAS Publisher | Integrated Local and Systemic Vancomycin Therapy for MRSA-Induced Osteomyelitis and Septic Non-Union

Integrated Local and Systemic Vancomycin Therapy for MRSA-Induced Osteomyelitis and Septic Non-Union

DOI : https://doi.org/10.36349/easjop.2025.v07i04.009

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Methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis is difficult to treat due to multidrug resistance, biofilm formation, and the need for prolonged intravenous therapy. This observational study involved 14 patients (6 chronic osteomyelitis, 8 septic non-union; age 14–78 years), all with MRSA sensitive only to vancomycin. Treatment included surgical debridement, high-dose local vancomycin via polymethylmethacrylate (PMMA) beads or coated nails, and a short intravenous vancomycin course with oral linezolid in selected cases. All patients achieved infection cure; fracture union occurred in all septic non-union cases, with no systemic toxicity. High local antibiotic delivery improved outcomes and reduced hospitalization, though PMMA required secondary removal. Dual mode vancomycin therapy appears effective for MRSA osteomyelitis and septic non-union, but larger controlled trials are needed for validation.

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