Diabetic foot complications remain a leading cause of disability and hospitalization among diabetic patients, particularly in low-resource settings such as Cameroon. This study conducted a comparative quantitative analysis to assess the knowledge and perception of diabetic foot care among nurses and primary caregivers in selected regional hospitals. A cross-sectional design was employed, using structured questionnaires to collect data from 101 nurses and 173 caregivers. Descriptive and inferential statistics, including chi-square and t-tests, were used to analyze differences between the two groups. Results revealed that 96.1% of nurses demonstrated adequate knowledge, while only 49.9% of caregivers achieved similar scores. Similarly, 96.1% of nurses positively perceived diabetic foot care, compared to 38.7% of caregivers. Educational level, prior exposure to diabetic education, and professional experience were significantly associated with knowledge levels. Challenges identified included a lack of training opportunities for caregivers and systemic constraints for nurses. The findings highlight the urgent need for integrated caregiver education, improved interdisciplinary collaboration, and institutional support for frontline healthcare workers. The study contributes to existing literature by offering a dual-perspective analysis that underscores the importance of both formal and informal care providers in chronic disease management. It calls for inclusive, community-integrated interventions to reduce preventable complications and improve health outcomes for diabetic patients.