Aphrodisiac substance could be drug, food or drink that increase libido, enhance sexual pleasure, induce and sustain erection thus leading to sexual satisfaction. Several people across the globe employ aphrodisiac substance to enhance their sexual performance and this has been a routine for them more especially, when meeting a new sexual partner for the first time. The aim of this study is to evaluate the Rising Trend of Aphrodisiac Substance Usage during Sex among Male in South-South Nigeria. This was a descriptive cross-sectional study involving 250 males. A well-structured questionnaire was administered to participants. The study lasted for a period of 3 months. Inclusion criteria were males between 18-47 years old. Exclusion criteria were those males that were above 47 years of age. Data were analyzed with SPSS version 25.0 and p < 0.05 was significant. The results revealed that the participants were between 18 – 47 years (most of them are between 28 to 32 years) old, 48.0% had secondary level of education, 60.0% were single, 40.0% were business men, 60.0% knew aphrodisiac substance, 76.0% used aphrodisiac substance, 60.0% like using aphrodisiac substance, 76.0% always and frequently used aphrodisiac substance. This research shows that the use of aphrodisiac substance is on the increase among young men and this usage is to enhance sexual arousal and sustain erection during sexual intercourse.