EAS Publisher | Molecular Mechanisms of Bombyx mori Nucleopolyhedrovirus (BmNPV) Entry and Replication in Silkworm Cells: A Review

Molecular Mechanisms of Bombyx mori Nucleopolyhedrovirus (BmNPV) Entry and Replication in Silkworm Cells: A Review

DOI : https://doi.org/10.36349/easjpid.2025.v07i02.004

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Bombyx mori Nucleopolyhedrovirus (BmNPV) is a baculovirus that has been a major threat to the sericulture industry for decades. Through its envelope protein, P64, which interacts with the host receptor, Bombyx mori gp64, BmNPV attaches itself to silkworm cells. Clathrin-mediated endocytosis is the next mechanism by which the virus enters cells. After much research, the entrance mechanisms of BmNPV were shown to be a multi-step, intricate process. BmNPV first attaches itself to the surface of the host cell through its envelope protein, P64. Actin polymerization and clathrin-mediated endocytosis are two processes that are triggered by this contact and aid in the internalization of viruses. After entering, BmNPV uses the resources of the host cell to travel to the nucleus, where it replicates. The paper review the virus's history, entry mechanisms, and replication strategies.

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