Background: The amount of strain that cardiac surgery exerts on blood bank services is an example that emphasises the need for multimodal blood conservation strategy. The most common factor which is being attributable to increase bleeding after cardiac surgery is hyperfibrinolysis. Thererfore the use of antifibrinolytics during high risk cardiac surgery becomes inevitable. Commonly used antifibrinolytic include Tranexamic Acid(TA) and Epsilon-amino-caproic acid (EACA) .The aim of our study was to compare the effectiveness of both TA and EACA in reducing post-surgical bleeding in on-pump CABG surgeries and to assess the post-operative complications associated with its use.Material and Methods: After obtaining informed written consent, approval of ethics and research committee patients who were scheduled for on-pump CABG were included in the study. Patients were divided into two groups randomly by using a comupter generated randomized block design namely group TA(n=40) and group EACA (n=40). TA group received tranaxamic acid at a dose of 10mg/kg IV over 20 min at the time of induction then 1-2 mg/kg in CPB prime followed by 1 mg /kg/hr infusion during surgery. Group EACA received EACA in a dose of 100mg/kg/IV over 20 min at the time of induction then 5-10mg/kg in CPB prime followed by 10mg/kg/hr. infusion during surgery. Patients were assessed for blood loss and were monitored for fibrinogen level and D- dimer levels. Other parameters which were assessed included Re-exploration and post-operative complications. Result: Primary outcomes like bleeding at 4hrs, there was no significant difference between the groups but when total bleeding at 24hrs. was compared there was a significantly lesser bleed in group TA group compared to group EACA (P=0.0022).The requirement of PRBC in group TA was for 3 patients, where as in EACA group 4 patients required PRBC (P>0.05).There was no significant difference in the rate of post-operative complications between the groups.(P>0.05)