Median nerve neuropathy, which is characterized by pain, reduced muscular strength, and restricted nerve movement, is increasingly associated with long-term computer use. This study investigated in symptomatic computer users the effect of muscle strengthening exercises alone vs a combination of strengthening exercises and median nerve manipulation in 30 symptomatic computer users. Before conducting the four-week experiment, volunteers in Group A were split into two groups and had been selected out of 90 individuals to receive conservative treatment (muscle strengthening exercises) whilst Group B received both muscle strengthening and Butler's median nerve mobilization procedure. Pain and muscle strength were assessed using Visual Analog Scale (VAS) and Medical Research Council (MRC) grading respectively. Both groups separately showed significant improvement (p < 0.001) though Group B had a relatively more reduction in discomfort and gain in muscle strength than Group A and recommends that in computer users, a synergy of neural mobilization with usual strengthening exercises is more effective in moderating median nerve neuropathy signs. They recommend larger scale studies with objective evaluations in the future.