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An Analysis of Clinical Profile and Outcome in Scrub Typhus Patients Requiring Intensive Care Management in a Tertiary Care Hospital

DOI : https://doi.org/10.36349/easjacc.2020.v02i03.004
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Introduction:Scrub typhus is a zoonotic disease caused by rickettsea Orientia tsutsughamushi .It is characterised by acute febrile illness with multiorgan dysfunction.Crop fields are the main reservoir for transmission hence infected when accidentally exposed to mite infested areas.In the pre-antibiotic era scrub typhus was considered as a lethal disease and continues to be major health problem in south Asia and west Pacific regions.Mortality of Scrub typhus ranges from 7% to 30% next to malaria among infectious diseases. Methods: All patients had a full work up for fever that included three smears for malarial parasites, serology for dengue, leptospirosis, scrub typhus, enteric fever, blood, urine,sputum or endotracheal cultures and other tests as clinically indicated.A diagnosis of scrub typhus was made when a patient is tested positive for IgM ELISA and other causes of fever excluded. Results: total patients,the vasopressor requirements being Dopamine (7%) , Nor adrenaline(12.7%) and Vasopressin(2.8%).1.4% received packed red blood cell transfusions whereas 16.9% had platelet transfusions . 40.8% required non invasive ventilation whereas 8.5% required invasive mechanical ventilation and 1.4% required both non invasive and invasive mechanical ventilation . 1.4% of patients required haemodialysis.The mean duration of ICU and hospital stay were 4.56 and 6.98 days respectively. In hospital mortality was 1.4%. Conclusion: In our study we hereby conclude that the incidence of organ dysfunction is highly variable compared with other studies whereas the in hospital mortality was relatively low.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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