Coronaviridae family from which coronavirus descends is the recent major health concern that threats the humanity worldwide. The novel flu-like coronavirus disease COVID-19 is responsible for infecting 2,257,789 individual as of 18th of April. COVID-19 health consequences include acute respiratory distress syndrome ARDS, pneumonia, hypoxic lung, sepsis multi-organ failure, respiratory arrest and eventually causing death. Interestingly, pneumonia caused by novel coronavirus was associated with coagulopathy disorder, elevated D-dimer, fibrin degradation product, disseminated intravascular coagulation DIC all are part of the hyper coagulability status of COVID-19 patients. the most commonly drugs used now to treat COVID19 symptoms is causing serious cardiac adverse reaction such as QTc prolongation caused by the combination of HCQ and Azithromycin which is the most commonly used regimen for the treatment of COVID19, here comes the role of magnesium sulfate (MgSO4) which is an inorganic salt commonly known as Epsom salt as an adjunctive therapy as extended release infusion to the patients suffering from previous serious conditions and their complications that the patients may develop in late stage of the disease. Magnesium sulfate is a cheap, safe and readily available medication can be a drug of choice in supportive treatment of COVID-19 especially critically ill patients with promising crucial beneficial medical effects.