Abstract: The caregivers of an autistic child experience reminiscent level of anxiety, pressure and mood swings that have major negative impact on their own overall physical and mental health and well-being as well as the health of their special children. Adequate level of social support and positive personality traits enhances the mental well-being of the caregivers and with the help of this they can achieve inner strength and well-being to overcome ups and downs of their life. The present research study examined the impact of HEXACO personality traits and social support on mental well-being among the One hundred (100) caregivers of children with ASD. Study also highlighted that the mental health of the caregivers is equally important as the physical health as well as not only the health of the children is important but health of the caregivers is more important for normal functioning. HEXACO-PI-R, Multidimensional Scale of Perceived Social Support and Warwick-Edinburgh Mental Well-being Scale used as a measuring tool in this study. Data were collected by using purposive sampling technique. Pearson Product Moment Correlation Coefficient and Multiple Linear Regression Analysis (Stepwise) administer to test the results. Results indicated strong and healthy social support, positive mental health and dispositions helps caregivers to tackle the stressful situations easily and prepare them to face challenges related to the behavior of their special child. It also aid caregivers to stay resilient and confident in any adverse situations. Their psychological health difficulties can be reduced by behavioral interventions and various orientation and awareness programs, fixed avocation and higher income, decreased symptomatic behaviors of ill reliant.