Toxins can alter the nervous system in ways that can disrupt or damage the brain or peripheral nervous system because of repeated exposure to natural or man-made toxic substances. The present study aims to investigate the neuro-behavioral and cytoarchitecture protective functions of rutin and vitamin C in monosodium glutamate and alcohol induced neurotoxicity in male Wistar rats. After two weeks of acclimatization, the animals were randomly selected into ten (10) groups with each group having five animals each (n=5). Neurotoxicity was induced with an oral single daily administration of 30% alcohol and 1.5g/kg body weight of Monosodium glutamate for 28 days consecutively in all rat groups except group1. The animals were subsequently treated as follows: Group 1: Control; animals in this group had free access to water and laboratory rat chow. Group 2: MSG only; animals in this group received no additional treatment after induction of neurotoxicity with a single daily administration of 1.5g/kg of MSG. Group 3: Alcohol only; animals in this group received no additional treatment after induction of neurotoxicity with a single daily administration of 30% alcohol. Group 4: MSG + Alcohol; animals in this group got no treatment after the induction of neurotoxicity with a single daily administration of 1.5g/kg of MSG and 30% alcohol. Group 5: MSG + Alcohol + Rutin; animals in this group received 30mg/kg of rutin following induction of neurotoxicity. Group 6: MSG + Alcohol + Vitamin C; animals in this group received 200mg/kg of vitamin C following induction of neurotoxicity. Group 7: MSG + Rutin; animals in this group received 30mg/kg of rutin following induction of neurotoxicity. Group 8: MSG + Vitamin C; animals in this group received 200mg/kg of rutin following induction of neurotoxicity. Group 9: Alcohol + Rutin; animals in this group received 30mg/kg of rutin following induction of neurotoxicity. Group 10: Alcohol + Vitamin C; animals in this group received 200mg/kg ...