Coronavirus disease (COVID_19) is an emerging respiratory virus. The World Health Organization (WHO) declared COVID-19 a global pandemic. Health professionals are looking forward to effectively and safely treat the infected patient by drug repositioning or to develop a vaccine and prevent the contagion. Recently, researchers tried to find a treatment for COVID-19 ,such as hydroxychloroquine . HCQ have side effects as Gastrointestinal upset (vomiting and diarrhea), Patients with long-term exposure to HCQ suffer from severe side effects, such as retinopathy, circular defects (or bull’s eye maculopathy) , HCQ are metabolized in the liver with renal excretion of some metabolites, hence they should be prescribed with care in people with liver or renal failure, there is raise concerns about reports of COVID-19 causing liver and renal impairment, which may increase the risk of toxicity of HCQ when it is used to treat COVID-19. this problem leading us to looking for a safer alternative. The treatment of COVID-19 still not optimize, depending on treating symptoms or the complication patient develops and monitoring. Also, considering risk factors for the disease. Propranolol is the best alternative for HCQ as an effective and safe drug. At this review we have suggested propranolol which is a nonselective beta-blocker that blocks the action of catecholamines (adrenaline and noradrenaline) at both beta-1 and beta-2 adrenergic receptors ) to be used safely as renin inhibitor , red blood cell invasion inhibitor, cardiovascular complication mitigator , and anticatabolizer in management of complicated COVID-19 infected patients with positive clinical outcomes.